The Philosophy of Evidence-based Medicine by Howick Jeremy H

Author:Howick, Jeremy H. [Howick, Jeremy H.]
Language: eng
Format: mobi
Publisher: Wiley-Blackwell
Published: 2011-07-21T16:00:00+00:00

These examples suffice to show that additivity cannot be taken for granted. Even where additivity might hold, however, another assumption must be made to support the claim that PCTs provide a measure of absolute effect size: the performance of the placebo controls must be legitimate and perform consistently.

Unless placebo controls are legitimate, they do not provide a baseline against which the characteristic effects (absolute or not) of the treatment can be measured. But we saw in the last chapter that placebo controls are not always legitimate. Likewise, the Moerman and Patel studies indicate that the wide variability of placebo control treatments (legitimate or not) can determine how effective an experimental treatment appears. It would indeed be a strange definition of absolute effect size that was compatible with the effect size changing drastically from study to study.

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